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Sains Malaysiana
52(7)(2023):
http://doi.org/10.17576/jsm-2023-5207-14
Advances in the
Bioregulation of Mesenchymal Stem Cells by Low-Level Laser Therapy during Bone
Formation: A Narrative Review
(Kemajuan dalam
Kawal Atur Sel Stem Mesenkima oleh Terapi Laser Tahap Rendah semasa
Pembentukan Tulang: Kajian Naratif)
WANG YAN PEI1,
MOHAMAD ARIF AWANG NAWI1 & NORMA AB RAHMAN2,*
1School of Dental Sciences, Universiti Sains Malaysia,
Health Campus,16150 Kubang Kerian, Kelantan, Malaysia
2Orthodontic Unit, School of Dental Sciences,
Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan,
Malaysia
Received: 11
November 2022/Accepted: 5 July 2023
Abstract
This article reviews the progress of research on the modulation of the
biological effects of low-level laser therapy (LLLT) on Mesenchymal stem cells
(MSC) and the influence of the basic LLLT parameters and irradiation scenarios. A thorough search of the literature
in the PubMed, Web of Science and
Embase databases, including articles
published in peer-reviewed journals, was conducted to collect relevant
information on LLLT and MSCs. A comprehensive search of PubMed, Web of Science,
and Embase databases was performed using the keywords "Low level
laser," "mesenchymal stem cells," " cell
proliferation," and "osteogenic differentiation." The search was
limited to studies published in English between 2009 and 2022, including in
vitro and in vivo studies. LLLT has the potential to
promote MSC proliferation and osteogenic differentiation, with significant
applications in bone tissue engineering. Factors that influence the biological
effects of LLLT on MSC include cell type, culture medium, duration of
irradiation, the frequency of laser irradiation, irradiation spot size, and
type of light flux distribution. The limitations of this review include
heterogeneous experimental conditions and the inability to design experiments
that consider all influencing factors simultaneously.
Keywords: Cell proliferation; low level laser; mesenchymal
stem cells; osteogenic differentiation
Abstrak
Artikel
ini mengkaji kemajuan penyelidikan mengenai modulasi kesan biologi terapi laser
peringkat rendah (LLLT) pada sel stem mesenkima (MSC) dan pengaruh parameter
LLLT asas dan senario penyinaran. Pencarian teliti kepustakaan dalam pangkalan
data PubMed, Web of Science dan Embase, termasuk artikel yang diterbitkan dalam
jurnal semakan rakan sebaya, telah dijalankan untuk mengumpul maklumat yang
berkaitan tentang LLLT dan MSC. Carian komprehensif pangkalan data PubMed, Web
of Science dan Embase telah dilakukan menggunakan kata kunci ‘laser tahap
rendah’, ‘sel stem mesenkima’, ‘percambahan sel’ dan ‘pembezaan osteogenik’.
Pencarian terhad kepada kajian yang diterbitkan dalam bahasa Inggeris antara
2009 dan 2022, termasuk kajian in vitro dan in vivo. LLLT
berpotensi untuk menggalakkan percambahan MSC dan pembezaan osteogenik dengan
aplikasi penting dalam kejuruteraan tisu tulang. Faktor yang mempengaruhi kesan
biologi LLLT pada MSC termasuk jenis sel, medium kultur, tempoh penyinaran,
kekerapan penyinaran laser, saiz tempat penyinaran dan jenis taburan fluks
cahaya. Kekangan dalam ulasan ini termasuk keadaan uji kaji heterogen dan
ketidakupayaan untuk mereka bentuk uji kaji yang mempertimbangkan semua faktor
yang mempengaruhi secara serentak.
Kata kunci: Laser tahap rendah; pembezaan osteogenik;
percambahan sel; sel stem mesenkima
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*Corresponding author; email: drnorma@usm.my
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